Endocrine Abstracts

Peptide YY (PYY) is a satiety hormone that communicates nutritional status to the central nervous system. PYY is released postprandially from endocrine L-cells in proportion to calories consumed. It is processed to generate the principle bioactive form PYY3–36, which acts on Y2 receptors in feeding centres within the brainstem and hypothalamus to reduce appetite. Chronic intravenous infusion of PYY3–36 induces weight loss in rodents, and obese humans display low plas...